Phenobarbitone (Phenobarbital)
Phenobarbitone (Phenobarbital) controls epilepsy, seizures, and provides sedative-hypnotic action. It enhances GABA activity, prolonging chloride influx for CNS depression. Chemical Formula: C₁₂H₁₂N₂O₃ Mechanism of Action: Enhances GABA-A activity, prolongs Cl⁻ channel opening. Also reduces glutamate-mediated excitation. Therapeutic Uses of Phenobarbitone (Phenobarbital): Tonic-clonic seizures Partial seizures Status epilepticus (alternative) Febrile seizures (children) Side Effects of Phenobarbitone … Read more
