Mediators of Inflammation

• Mediators Inflammation is regulated by various chemical mediators that orchestrate the inflammatory response.
• The Mediators can be derived from cells or plasma and have different roles in initiating and sustaining inflammation. Top of Form
• Its inflammation are substances that play key roles in initiating and regulating inflammatory responses.

Main Types of Inflammatory Mediators

1. Histamine

   • Source: Released by mast cells and basophils.
   • Function: Increases vascular permeability and causes vasodilation, leading to redness and swelling.

2. Prostaglandins

   • Type: Lipid compounds.
   • Function: Intensify inflammation by promoting vasodilation, fever, and pain.

3. Cytokines

   • Examples: Interleukins and Tumor Necrosis Factor (TNF).
   • Function: Proteins that modulate the immune response and regulate inflammation.

4. Chemokines

   • Type: A subset of cytokines.
   • Function: Attract white blood cells to sites of infection or injury (chemotaxis).

5. Complement System

   • Description: A series of plasma proteins.
   • Function: Enhances the ability of antibodies and phagocytic cells to clear microbes and damaged cells.

6. Leukotrienes

   • Type: Lipid compounds.
   • Function: Mediate allergic and inflammatory responses by increasing vascular permeability and attracting leukocytes

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