- Adrenocorticotropic Hormone (ACTH): Used diagnostically in adrenal insufficiency and therapeutically in some inflammatory diseases.
- Adrenocorticotropic Hormone (ACTH): Stimulates adrenal cortex to produce cortisol and other glucocorticoids.
Physiology:
- Produced by the anterior pituitary, ACTH stimulates the adrenal cortex to produce glucocorticoids (cortisol) and, to a lesser extent, mineralocorticoids.
ACTH Analogues:
- Synthetic ACTH (e.g., Cosyntropin):
- Uses: Diagnostic tool for adrenal insufficiency (ACTH stimulation test).
- Mechanism: Stimulates cortisol production from the adrenal cortex.
Clinical Applications:
- Diagnosis: Evaluates adrenal gland function.
- Therapeutic Use: Occasionally used for infantile spasms and specific conditions.
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Adverse Effects:
- Similar to glucocorticoid excess if used long-term, including hypertension, hyperglycemia, and fluid retention.
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