Physiological Properties Affecting Drug Distribution include blood flow, tissue permeability, protein binding, and body water content. Physiological Properties Affecting Drug Distribution The distribution of a drug in the body is influenced by several physiological properties: Lipid Solubility Highly lipid-soluble drugs (e.g., diazepam, propofol) distribute more readily into lipid-rich tissues like the brain and adipose tissue. … Read more

Tissue Permeability of Drugs depends on lipid solubility, ionization, molecular size, and membrane transport mechanisms. Tissue permeability refers to the ability of drugs to cross cell membranes and enter tissues, influencing drug distribution and therapeutic action. It depends on both drug properties and physiological barriers. Factors Influencing Tissue Permeability Lipid Solubility Lipid-soluble drugs easily diffuse … Read more

Binding of Drugs involves reversible interaction with plasma proteins and tissues, affecting distribution, action, and elimination. Drug binding refers to the interaction of drugs with various body components, including proteins, enzymes, receptors, DNA, and ions. This binding influences drug distribution, efficacy, metabolism, and potential drug-drug interactions. Protein binding is the most common type, where drugs … Read more

Mechanisms of Drug Absorption Through the GIT explain passive diffusion, active transport, and endocytosis in biopharmaceutics. Mechanisms of Drug Absorption Through the GIT When a drug is administered orally (peroral route), it must traverse several barriers in the gastrointestinal tract before reaching systemic circulation. The main mechanisms include: Passive Diffusion Passive diffusion is the most … Read more

Introduction to Biopharmaceutics explores drug absorption, distribution, metabolism, and excretion with focus on therapeutic effectiveness. Introduction to Biopharmaceutics Definition and Scope Biopharmaceutics studies the interrelationship between a drug’s physical, chemical, and biological properties and its absorption, distribution, metabolism, and excretion. It connects drug formulation with its therapeutic effects. Importance in Drug Development and Therapy Formulation … Read more