Butamben is an ester-type local anesthetic used topically for pain relief by blocking nerve signal transmission. Structure of Butamben It is an amino benzoic acid derivative with a butyl ester group attached to the benzene ring, providing enhanced anesthetic properties. Chemical Formula: C₁₀H₁₉NO₂ Mode of Action Sodium Channel Blockade: Blocks nerve impulse transmission by inhibiting … Read more

Benzocaine is an ester-type local anesthetic commonly used topically to relieve pain and itching by blocking nerve signals. Structure of Benzocaine Benzocaine is a simple amino benzoic acid derivative with a diethylamino group attached to the benzene ring, enhancing its lipophilicity and anesthetic properties. Chemical Formula: C₇H₉NO₂ Mode of Action Sodium Channel Blockade: Inhibits voltage-gated … Read more

Meprylcaine is an ester-type local anesthetic that provides surface and infiltration anesthesia by blocking nerve impulse conduction. Structure of Meprylcaine It is a synthetic local anesthetic with a diethylaminoethyl substituent attached to a benzamide core. Chemical Formula: C₁₁H₂₂N₂O Mode of Action Sodium Channel Blockade: Inhibits nerve impulse transmission by blocking voltage-gated sodium channels. Extended Duration: … Read more

Hexylcaine is an ester-type local anesthetic used for surface anesthesia by blocking nerve impulse conduction. Structure of Hexylcaine It is a synthetic local anesthetic with a benzocaine-like structure, featuring a hexyl ester group attached to a benzoic acid core. Chemical Formula: C₁₀H₁₇NO₂ Mode of Action Sodium Channel Inhibition: Blocks nerve impulse conduction by inhibiting voltage-gated … Read more

Cocaine is a natural ester local anesthetic that blocks nerve conduction and is also known for its stimulant and addictive properties. Structure of Cocaine It is a naturally occurring local anesthetic derived from the coca plant, featuring a tropane ring system with a benzoyl and methyl ester substituent. Chemical Formula: C₁₇H₂₃NO₄ Mode of Action Sodium … Read more

Classification of Local Anesthetics is based on their chemical structure, mainly ester-linked and amide-linked agents, with differing duration and use. Classification of Local Anesthetics Local anesthetics are categorized based on their chemical structure. Each class shares a common mechanism of action, primarily involving the inhibition of nerve impulse transmission. Below is the classification along with … Read more

Local anesthetics are drugs that block nerve conduction at the site of administration, causing temporary loss of sensation without unconsciousness. Definition: Local anesthetics are medications that temporarily block sensation in a specific area of the body without affecting consciousness. They are commonly used during surgical, dental, and diagnostic procedures to prevent or relieve pain. Mechanism … Read more

SAR of Local anaesthesia SAR of Local Anaesthesia shows how lipophilic group, intermediate chain, and amine group influence potency, duration, and activity. Aromatic Group (Lipophilic End): Typically, a benzene ring, responsible for lipophilicity, enabling penetration of nerve cell membranes. Potency is proportional to lipid solubility, influencing membrane penetration. Intermediate Chain (Linker): Connects the aromatic group … Read more