Alpha Adrenergic Blockers

• Alpha Adrenergic Blockers inhibit the activation of alpha-adrenergic receptors (α1 and α2), leading to vasodilation and decreased blood pressure.
• These drugs are commonly used for Alpha Adrenergic Blockers conditions such as hypertension, pheochromocytoma, and benign prostatic hyperplasia (BPH).

Classification:

• Alpha blockers are classified into non-selective and selective types:

1. Non-Selective (α1 and α2 blockers)

   • These block both α1 and α2 receptors, leading to vasodilation but may also cause reflex tachycardia.
   • Example drugs: Tolazoline, Phentolamine, Phenoxybenzamine

2. Selective Alpha-1 Blockers (α1 blockers)

   • These specifically block α1 receptors, leading to relaxation of smooth muscle and reduction in blood pressure with minimal reflex tachycardia.
   • Example drugs: Prazosin

3. Ergot Alkaloids (Partial α-adrenergic blockers)

   • These drugs have partial alpha-blocking effects and are used for migraine prophylaxis and vascular disorders.
   • Example drugs: Dihydroergotamine, Methysergide

Effects of Alpha Blockers

• Vasodilation → Decreased blood pressure
• Reduced peripheral resistance
• Increased heart rate (reflex tachycardia in non-selective blockers)
• Relaxation of smooth muscles in the bladder and prostate

Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!