Alzheimer’s Disease (AD) is a chronic neurodegenerative disorder that gradually impairs memory, thinking, and behavior. Marked by progressive cognitive decline, personality changes, and loss of independence, it is the most common cause of dementia in older adults. With no complete cure, early diagnosis, proper treatment, and supportive care play a key role in slowing progression and improving quality of life.
Overview of Alzheimer’s Disease (AD):
Alzheimer’s disease is a progressive neurodegenerative disorder characterized by:
- Loss of cholinergic neurons in the basal forebrain
- Accumulation of beta-amyloid plaques and neurofibrillary tangles (tau protein).
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Main symptoms:
- Memory loss
- Cognitive decline
- Disorientation
- Language problems
Pharmacological Goals:
- Enhance cholinergic neurotransmission
- Prevent neuronal damage and glutamate excitotoxicity
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