Ambenonium Chloride

• Ambenonium Chloride is a synthetic quaternary ammonium compound classified as a cholinesterase inhibitor.
• It functions by reversibly inhibiting the enzyme acetylcholinesterase, thereby increasing the concentration of acetylcholine at neuromuscular junctions.

Chemical Formula:

• C₂₀H₂₈Cl₂N₄O₂
• 

Mechanism of Action:

• Reversible AChE inhibitor
• Does not cross BBB

Uses of Ambenonium Chloride:

• Myasthenia gravis (alternative to neostigmine/pyridostigmine)

Side Effects of Ambenonium Chloride:

• Similar to other cholinesterase inhibitors:
  • GI cramps
  • Salivation
  • Bradycardia

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