Amlodipine is a long-acting calcium channel blocker used in angina and hypertension by relaxing blood vessels and lowering heart workload.
Structure of Amlodipine
- Amlodipine is a dihydropyridine calcium channel blocker with a substituted phenyl ring and an ethyl group attached to the dihydropyridine core.
- Chemical Formula: C₂₀H₂₄N₂O₅
Mode of Action
- Calcium Channel Blocking: Inhibits L-type calcium channels predominantly in vascular smooth muscle.
- Vasodilation: Causes peripheral arterial dilation, reducing blood pressure and cardiac workload.
- Prolonged Action: Long half-life allows once-daily dosing with sustained effects.
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Uses
- Hypertension: Lowers blood pressure effectively with minimal side effects.
- Angina Pectoris: Prevents and alleviates chest pain by improving myocardial oxygen supply.
- Coronary Artery Disease: Enhances coronary blood flow.
- Prevention of Stroke: Indirectly reduces stroke risk by controlling hypertension.
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