- Aspirin: A non-steroidal anti-inflammatory drug (NSAID) used for pain, fever, and inflammation.
- Aspirin: Also prevents blood clots by inhibiting platelet aggregation.
MOA:
- Irreversibly inhibits COX-1 and COX-2, blocking prostaglandin and thromboxane A2 synthesis, reducing pain, inflammation, fever, and platelet aggregation.
Pharmacological Actions:
- Anti-inflammatory
- Analgesic (pain relief)
- Antipyretic (fever reduction)
- Antiplatelet (prevents clotting)
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Pharmacokinetics:
- Absorption: Rapid via stomach and intestine.
- Metabolism: Liver (to salicylic acid).
- Excretion: Urine, with dose-dependent kinetics.
Adverse Effects
- GI issues: Ulcers, bleeding.
- Bleeding risk: Prolonged clotting time.
- Renal injury, hypersensitivity, tinnitus.
- Reye’s syndrome (in children with viral infections).
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