Atropine Sulfate

  • Atropine Sulfate treats bradycardia, reduces secretions, and acts as an antidote in organophosphate poisoning.
  • Atropine Sulfate blocks muscarinic receptors, producing anticholinergic effects for smooth muscle relaxation and eye dilation.

Formula:

  • (C₁₇H₂₃NO₃)₂·H₂SO₄

Chemical Structure of Atropine Sulfate

Mechanism of Atropine Sulfate:

  • Competitive muscarinic receptor antagonist
  • Affects M1–M5; especially heart (M2) and secretory tissues (M3)

Uses:

  • Bradycardia
  • Pre-anesthetic (reduce secretions)
  • Organophosphate poisoning (alongside 2-PAM)
  • Mydriasis & cycloplegia
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Side Effects of Atropine Sulfate:

  • Dry mouth
  • Blurred vision
  • Urinary retention
  • Tachycardia
  • CNS stimulation (high doses)

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