Reactions of Indole

Reactions of Indole

Reactions of Indole include electrophilic substitution, oxidation, reduction, and cyclization pathways vital in drug synthesis. Reactions of Indole Electrophilic Substitution (EAS) Very reactive at C-3 (due to resonance stabilization of carbocation intermediate). Secondarily reactive at C-2. Examples: Nitration: dilute HNO₃ → 3-nitroindole Halogenation: Br₂ → 3-bromoindole Friedel–Crafts acylation: at C-3 Vilsmeier–Haack Reaction: POCl₃/DMF → 3-formylindole … Read more

Basicity of Pyridine

Basicity of Pyridine

Basicity of Pyridine explains its nitrogen lone pair, resonance effects, and comparison with pyrrole and aliphatic amines. The basicity of pyridine refers to its ability to accept a proton (H⁺), which depends on the availability of its lone pair of electrons on the nitrogen atom. Structure and Basicity Pyridine is an aromatic heterocycle with the … Read more

Thixotropy (Time-Dependent Shear-Thinning)

Thixotropy (Time-Dependent Shear-Thinning)

Definition of Thixotropy (Time-Dependent Shear-Thinning): Thixotropy (Time-Dependent Shear-Thinning) is a time-dependent shear-thinning behavior. When a material is subjected to constant shear, its viscosity decreases over time. When the shear is removed, the material slowly regains its original viscosity. Key Features: Viscosity decreases with sustained shear. Recovery is reversible but time-dependent. Exhibits a hysteresis loop in … Read more

Dilatant Flow (Shear-Thickening)

Dilatant Flow (Shear-Thickening)

Definition of Dilatant Flow (Shear-Thickening): Dilatant Flow (Shear-Thickening) is seen in suspensions, protective gear, and industrial formulations. Dilatant fluids increase in viscosity with increasing shear rate. They become thicker and harder to move as more force is applied. Rheological Behavior: No yield stress Shear-thickening Flow curve is convex upward Equation (Power Law): $\tau = K … Read more

Pseudoplastic Flow (Shear-Thinning)

Pseudoplastic Flow (Shear-Thinning)

Definition of Pseudoplastic Flow (Shear-Thinning): Pseudoplastic Flow (Shear-Thinning) shows viscosity decreases with rising shear rate in fluids. Pseudoplastic fluids decrease in viscosity with increasing shear rate. The more you stir or apply shear, the thinner the fluid becomes.   Here’s the graph showing the shear-thinning behavior of a pseudoplastic fluid. As shear rate increases, the … Read more

Plastic Flow (Bingham Plastic)

Plastic Flow (Bingham Plastic)

Definition of Plastic Flow (Bingham Plastic): A plastic fluid (Bingham Plastic) behaves as a solid until a certain yield stress is exceeded. Beyond this point, it flows like a Newtonian fluid with a constant viscosity. Rheological Behavior: Requires minimum force (yield value) to initiate flow. Once flow starts, shear stress and shear rate are linearly … Read more

Non-Newtonian SystemsNon-Newtonian Systems

Non-Newtonian Systems

Non-Newtonian systems are fluids that do not follow Newton’s law of viscosity. Unlike Newtonian fluids (such as water or alcohol), their viscosity is not constant and varies depending on factors like shear rate, shear stress, and, in some cases, time. This makes them essential considerations in the formulation and behavior of various pharmaceutical products. Common … Read more

Size & Shapes of Colloidal Particles

Size & Shapes of Colloidal Particles

Size & Shapes of Colloidal Particles range from 1–1000 nm, influencing stability and optical properties. Size & Shapes of Colloidal Particles include spherical, rod-like, lamellar, and irregular forms. Size of Colloidal Particles: Range: 1 nm to 1000 nm (i.e., 10⁻⁹ m to 10⁻⁶ m). Size influences: Surface area Stability Interaction with biological membranes Drug release … Read more

Effect of Temperature on Viscosity

Effect of Temperature on Viscosity

Effect of Temperature on Viscosity is key in drug formulation, lubrication, and industrial processes. Effect of Temperature on Viscosity shows liquids thin as heat rises and molecules move faster. Viscosity is inversely related to temperature – as temperature increases, viscosity usually decreases. Why? At higher temperatures, the kinetic energy of molecules increases. This reduces intermolecular … Read more

Kinematic Viscosity

Kinematic Viscosity

Definition of Kinematic Viscosity: Kinematic viscosity is the ratio of dynamic viscosity to the density of the fluid. $\nu = \frac{\eta}{\rho}$ Where: ν = kinematic viscosity (units: m²/s or centistokes, cSt) η = dynamic viscosity (e.g., poise, centipoise) ρ = density of the fluid (e.g., g/cm³) Why is it important? It relates viscosity to the … Read more

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