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Pyrrole: Synthesis and Reactions include methods like Paal-Knorr synthesis and Knorr synthesis, with reactions such as electrophilic substitution at the 2-position. Synthesis of Pyrrole Hantzsch Pyrrole Synthesis Reagents: β-ketoester, ammonia or primary amine, and a 1,3-dicarbonyl compound Reaction: CH₃COCH₂COOEt  +  BrCH₂COCH₃  +  NH₃ →  Substituted pyrrole Knorr Pyrrole Synthesis Reagents: α-amino ketone + β-ketoester Mechanism: … Read more

Furan is a five-membered aromatic heterocyclic compound with one oxygen atom, used in pharmaceuticals and fine chemicals. Chemical Formula of Furan: C₄H₄O Physical Properties of Furan: Property Value Appearance Colorless, volatile liquid Odor Ether-like Boiling Point 31.4 °C Melting Point -85.6 °C Solubility Soluble in ether, alcohol; partially in water Density ~0.936 g/cm³ Medicinal Uses: … Read more

Furan: Synthesis and Reactions include Paal-Knorr synthesis and Feist-Benary synthesis, with electrophilic substitution as the main reaction. Synthesis of Furan Paal–Knorr Furan Synthesis Reagents: 1,4-dicarbonyl compound + acid catalyst (e.g., H₃PO₄ or p-TsOH) Reaction: O=CH–CH₂–CH₂–CHO   →   Furan  +  2H₂O Common method for synthesizing substituted furans Feist–Benary Synthesis Reagents: α-haloketone + β-dicarbonyl compound + base Cyclization … Read more

Pyrrole is a five-membered aromatic heterocyclic compound with one nitrogen atom, widely found in natural products and pharmaceuticals. Chemical Formula of Pyrrole: C₄H₅N Physical Properties of Pyrrole: Property Value Appearance Colorless to pale yellow liquid Odor Mild, pleasant Boiling Point 130 °C Melting Point -23 °C Solubility Soluble in alcohol and ether; slightly in water … Read more

Nomenclature of Heterocyclic Compounds follows IUPAC rules, naming based on ring size, heteroatom type, and saturation or unsaturation. Heterocycles are named using common (trivial) names or systematic IUPAC names. Common/Trivial Names These are historical or widely accepted names, commonly used for simple or well-known heterocycles. Examples: Aziridine (3-membered ring with N) Oxirane (epoxide, 3-membered ring … Read more

Classification of Heterocyclic Compounds is based on ring size, saturation, and heteroatoms, divided into aliphatic, aromatic, and fused systems. Classification of Heterocyclic Compounds Heterocyclic compounds are classified based on several criteria: By Ring Size Three-membered rings Saturated: Aziridine (N), Oxirane (epoxide with O) Unsaturated: Azirine, Oxirene Four-membered rings Saturated: Azetidine, Oxetane Unsaturated: Azetine, Oxete Five-membered … Read more

Thiophene is a five-membered aromatic heterocyclic compound with one sulfur atom, important in drugs, dyes, and conducting materials. Chemical Formula of Thiophene: C₄H₄S Physical Properties of Thiophene: Property Value Appearance Colorless to pale yellow liquid Odor Benzene-like Boiling Point 84 °C Melting Point -38 °C Solubility Soluble in organic solvents; poorly in water Density ~1.05 … Read more

Stereoselective Reactions are reactions where one stereoisomer is formed preferentially over others from the same reactant. Definition of Stereoselective Reactions: A stereoselective reaction is a chemical reaction in which a single reactant can produce two or more stereoisomeric products, but one is formed preferentially over the others. The preference arises due to factors like steric … Read more

Stereospecific Reactions are chemical reactions where a specific stereoisomer of the reactant always leads to a specific stereoisomer of the product. Definition of Stereospecific Reactions: A stereospecific reaction is one where the stereochemistry of the reactant completely determines the stereochemistry of the product. Each stereoisomeric reactant leads to a different stereoisomeric product. The reaction mechanism … Read more