Anti-Histaminic & Anti-Neoplastic Agents Notes [U-1]
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ANTI-HISTAMINIC AGENTS
- Histamine
- Histamine Receptor
- Classification of antihistamine
- H-1 antagonists
- Structure-Activity Relationship (SAR) of H₁ Receptor Antagonist Antihistamines
First generation H1-Antagonist
- Diphenhydramine Hydrochloride
- Dimenhydrinate
- Doxylamine Succinate
- Clemastine Fumarate
- Diphenylpyraline Hydrochloride
- Triphelenamine Hydrochloride
- Chlorcyclizine Hydrochloride
- Meclizine Hydrochloride
- Buclizine Hydrochloride
- Chlorpheniramine Maleate
- Triprolidine Hydrochloride
- Phenidamine Tartrate
- Promethazine Hydrochloride
- Trimeprazine Tartrate
- Cyproheptadine Hydrochloride
Second generation H1-Antagonist
- Azatidine Maleate
- Astemizole
- Loratadine
- Cetirizine
- Levocetirizine
Mast Cell Stabilizers
- Cromolyn Sodium
- H₂ Antagonists (H₂ Blockers)
Various H2-Antagonist Drugs
- Cimetidine
- Famotidine
- Ranitidine
- Gastric proton pump inhibitor
Various gastric proton pump inhibitor
- Omeprazole
- Lansoprazole
- Rabeprazole
- Pantoprazole
Anti-Neoplastic Agents
- Cancer
- Anti-neoplastic agents
- Classification of Anti-Neoplastic Agents
Various Alkylating Agents
- Meclorethamine
- Cyclophosphamide
- Melphalan
- Chlorambucil
- Busulfan
- Thiotepa
Various Antimetabolites
- Mercaptopurine
- Thioguanine
- Fluorouracil
- Floxuridine
- Cytarabine
- Methotrexate
- Azathioprine
Various Antineoplastic antibiotics
- Dactinomycin
- Daunorubicin
- Doxorubicin
- Bleomycin
Plant Product
- Etoposide
- Vinblastine Sulphate
- Vincristine Sulphate
Miscellaneous
- Cisplatin
- Mitotane
Unit I: Antihistaminic and Anti-Neoplastic Agents – BPharma Notes Summary
This unit provides an in-depth understanding of antihistaminic agents and anti-neoplastic drugs, essential topics in medicinal chemistry.
Anti-histaminic Agents Notes
The unit begins with the study of histamine, its receptors (H₁ and H₂), and their distribution in the human body. It details the pharmacological role of H₁-antagonists, which are commonly used for allergies, motion sickness, and cold symptoms. Drugs covered include Diphenhydramine, Promethazine, Loratadine, Cetirizine, and others.
Next, the unit discusses H₂-antagonists like Cimetidine, Ranitidine, and Famotidine, which reduce gastric acid secretion and are widely used in ulcer treatment. It also introduces gastric proton pump inhibitors (PPIs) such as Omeprazole, Pantoprazole, and Lansoprazole, effective in treating acid-related disorders.
Anti-Neoplastic Agents
The second part of the unit covers anti-cancer drugs, categorized into several classes. These include alkylating agents (e.g., Cyclophosphamide, Melphalan), antimetabolites (e.g., Methotrexate, Fluorouracil), antibiotics (e.g., Dactinomycin, Doxorubicin), plant products (e.g., Vincristine, Etoposide), and miscellaneous agents like Cisplat
