Fermentation & Bioproduct Production Notes [U-5]

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Fermentation

  • Fermentation
  • General Requirements for Fermentation
  • Study of media
  • Equipment Used in Fermentation
  • Fermenter (Bioreactor) – Construction & Working
  • Sterilization methods
  • Aeration Process in Fermentation
  • Stirring (Agitation)
  • Large scale production fermenter design and its various controls

Industrial Production of Important Microbial Products

  • Production of Penicillins (Antibiotic)
  • Production of Citric Acid (Organic Acid)
  • Production of Vitamin B12 (Cyanocobalamin)
  • Production of Glutamic Acid (Amino Acid)
  • Production of Griseofulvin (Antifungal Antibiotic)

Blood Products

  • Whole Human Blood
  • Dried Human Plasma
  • Plasma Substitutes
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Other Units of Pharmaceutical Biotechnology

Unit 1
Unit 2
Unit 3
Unit 4
Pharmaceutical Biotechnology
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Other Subjects of B Pharmacy 6th Semester

Herbal Drug Technology

Topic wise notes of:

Herbal Drug Technology

  • Herbal Raw Materials & Indian Medicine Systems
  • Nutraceuticals: Uses, Herbs & Interactions
  • Herbal Cosmetics, Excipients & Formulations
  • Herbal Drug Evaluation, Patents & Regulations
  • Herbal Industry: Scope, GMP & Infrastructure
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Absorption & Distribution

Topic wise notes of:

Biopharmaceutics and Pharmacokinetics

  • Biopharmaceutics: Absorption & Distribution
  • Drug Elimination, Bioavailability & Bioequivalence
  • Pharmacokinetics Models, Dosing & Parameters
  • Multicompartment models
  • Nonlinear Pharmacokinetics
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Pharmacology III Respiratory and GI Tract

Topic wise notes of:

Pharmacology III

  • Respiratory & GI Tract Drug Pharmacology
  • Chemotherapy: Principles & Key Antibiotics
  • Chemotherapy: TB, Fungal & Parasitic Drugs
  • UTIs, Cancer Chemo & Immunopharmacology
  • Toxicology Basics & Chrono pharmacology
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Antibiotics & Aminoglycosides in Medicinal Chemistry III

Topic wise notes of:

Medicinal Chemistry III

  • Antibiotics & Aminoglycosides
  • Antibiotics & Antimalarials: Structures & SAR
  • Anti-TB, UTI & Antiviral Agents
  • Antifungals, Antiprotozoals & Sulfonamides
  • Intro to Drug Design & QSAR Approaches
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Pharmaceutical Quality Assurance

Topic wise notes of:

Pharmaceutical Quality Assurance

  • Quality Assurance, GMP, ICH, QbD & Quality System
  • GMP: Personnel, Premises & Equipment Control
  • Quality Control and Good Laboratory Practice
  • Complaints & Document Management
  • Calibration and Warehousing
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Summary: Fermentation & Bioproduct Production Notes

  1. Fermentation Methods & Requirements:
    • Involves microbial growth for product synthesis.
    • Requires suitable media, proper aeration, and stirring for optimal yield.
  2. Media, Equipment & Sterilization:
    • Media provides nutrients; must be sterilized (heat, filtration, chemicals).
    • Equipment includes fermenters, agitators, and air spargers.
  3. Aeration & Stirring:
    • Essential for oxygen transfer and uniform mixing in aerobic fermentation.
  4. Large-Scale Fermenter Design:
    • Includes temperature, pH, foam, and oxygen controls.
    • Equipped with sensors and control systems for optimal conditions.
  5. Industrial Product Fermentation:
    • Penicillin: Produced by Penicillium chrysogenum.
    • Citric Acid: From Aspergillus niger using molasses.
    • Vitamin B12: Fermented using Streptomyces or Pseudomonas species.
    • Glutamic Acid: By Corynebacterium glutamicum for use as MSG.
    • Griseofulvin: Antifungal agent from Penicillium griseofulvum.
  6. Blood Products:
    • Collection & Processing: Done under sterile conditions.
    • Storage: Includes whole blood, dried plasma, and plasma substitutes

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