Benazepril Hydrochloride is an ACE inhibitor used to treat hypertension by relaxing blood vessels and lowering blood pressure.
Structure of Benazepril Hydrochloride
- It is a prodrug ACE inhibitor with a benzimidazole core and a carbamate moiety.
- Chemical Formula: C₂₀H₃₄N₅O₆S·HCl
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Mode of Action
- Prodrug Activation: Metabolized to benazeprilat, the active form.
- ACE Inhibition: Prevents conversion of angiotensin I to angiotensin II, reducing vasoconstriction.
- Vasodilation: Leads to decreased systemic vascular resistance and blood pressure.
- Renal Protection: Reduces progression of renal disease in hypertensive and diabetic patients.
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Uses
- Hypertension: Lowers blood pressure effectively with once-daily dosing.
- Heart Failure: Improves symptoms and reduces mortality when used with other heart failure medications.
- Diabetic Nephropathy: Protects against kidney damage in diabetic individuals.
- Post-Myocardial Infarction: Aids in preventing adverse cardiac remodeling and improving survival.
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