Bepridil Hydrochloride is a calcium channel blocker used in angina to reduce heart workload and improve coronary blood flow.
Structure of Bepridil Hydrochloride
- It is a benzothiazepine derivative with a phenyl ring attached to a thiazepine ring containing multiple substituents.
- Chemical Formula: C₂₅H₃₈ClN₃OS
Mode of Action
- Calcium Channel Blocking: Inhibits L-type calcium channels in cardiac and vascular smooth muscle.
- Vasodilation: Causes relaxation of vascular smooth muscle, reducing blood pressure.
- Antiarrhythmic Effects: Prolongs refractory periods and suppresses abnormal heart rhythms.
- Other Effects: Exhibits anti-anginal and antiarrhythmic properties.
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Uses
- Hypertension: Lowers blood pressure through vasodilation.
- Angina Pectoris: Reduces myocardial oxygen demand and alleviates chest pain.
- Arrhythmias: Manages various cardiac arrhythmias.
Coronary Artery Disease: Improves coronary blood flow.
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