Bumetanide is a potent loop diuretic used to treat edema in heart failure and renal disorders by promoting fluid and electrolyte excretion.
Structure of Bumetanide
- Bumetanide is a loop diuretic similar to furosemide but with a more potent diuretic effect due to structural modifications.
- Chemical Formula: C₁₄H₂₄BrN₃O₅S
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Mode of Action
- Loop of Henle Inhibition: Blocks the Na⁺/K⁺/2Cl⁻ symporter in the ascending limb of the loop of Henle.
- Sodium, Potassium, Chloride Excretion: Promotes significant diuresis by increasing excretion of these ions.
- Calcium and Magnesium Retention: Enhances reabsorption of calcium and magnesium, reducing the risk of kidney stones.
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Uses
- Edema: Manages edema associated with congestive heart failure, renal disease, and liver cirrhosis.
- Hypertension: Lowers blood pressure by reducing blood volume.
- Hypercalcemia: Treats elevated calcium levels by promoting its excretion.
- Acute Pulmonary Edema: Provides rapid diuresis to alleviate fluid accumulation in the lungs.
- Hyponatremia: Addresses low sodium levels through increased sodium excretion.
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