Busulfan is an anti-neoplastic alkylating agent used mainly in chronic myeloid leukemia (CML) by suppressing bone marrow and inhibiting cancer cell growth.
Structure of Busulfan
- Busulfan is a bifunctional alkylating agent with two chloroethyl groups attached to a sulfur atom.
- Chemical Formula: C₄H₈Cl₂NS
Mode of Action
- DNA Alkylation: Forms interstrand and intrastrand crosslinks with DNA, disrupting replication and transcription.
- Bone Marrow Suppression: Reduces bone marrow activity, which is useful in preparing for bone marrow transplants.
- Inhibits Cell Division: Prevents proliferation of cancerous cells by damaging genetic material.
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Uses
- Chronic Myeloid Leukemia (CML): As part of conditioning regimens before bone marrow transplantation.
- Bone Marrow Transplantation: Used to ablate existing bone marrow.
- Other Hematological Malignancies: Such as acute lymphoblastic leukemia (ALL).
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