Production of Soft Gelatin Capsules ensures precise dosing, improved bioavailability, and enhanced stability of sensitive formulations. It ensures precise dosing, improved bioavailability, and enhanced stability of sensitive formulations. The production of soft gelatin capsules involves the following steps: Formulation of Fill Material: Drugs are dissolved or suspended in a suitable vehicle (e.g., oils, polyethylene glycol, … Read more
Importance of Base Adsorption and Minim/Gram Factors lies in selecting suitable suppository bases that can absorb the drug without altering its efficacy, ensuring uniformity and stability. Importance of Base Adsorption and Minim/Gram Factors is crucial for calculating the correct base quantity needed per dose, helping maintain accurate drug delivery and therapeutic effect Base Adsorption: Base … Read more
Size of capsules refers to the standardized dimensions of empty capsules, indicating their volume capacity. They range from 000 (largest) to 5 (smallest), used to encapsulate varying drug doses. Size of capsules determines the fill weight and patient compliance. Proper size selection ensures accurate dosing, ease of swallowing, and suitability for the intended formulation. Soft … Read more
Manufacturing Defects in Capsules: Include cracks, deformation, or uneven thickness. Manufacturing Defect in Tablets: May involve chipping, capping, or hardness issues. Causes: Poor materials, machinery faults, or improper handling. Hard gelatin capsules can exhibit defects during production or filling, such as: Cracks: Caused by improper drying or excessive brittleness of gelatin. Deformation: Due to improper … Read more
Nature of Shell and Capsule Content includes gelatin or non-gelatin materials that form the outer shell, designed for stability, protection, and ease of swallowing. Nature of Shell and Capsule Content also refers to the inner content—liquids, powders, granules, or semi-solids—formulated for accurate dosing and targeted drug release. Nature of the Shell: Soft gelatin capsules (soft … Read more
Soft gelatin capsules (soft gels) are a specialized form of capsules made from a single, pliable shell that encapsulates liquid or semi-solid formulations. Soft gelatin capsules are widely used in the pharmaceutical, nutraceutical, and cosmetic industries for delivering active pharmaceutical ingredients (APIs), oils, or other bioactive compounds. Key Features of Soft Gelatin Capsule: Composed of … Read more
In-Process and Final Product Quality Control Tests are essential for ensuring pharmaceutical product quality. In-Process and Final Product Quality Control Tests check parameters during manufacturing process and confirm safety, efficacy, and compliance before release. In-Process Quality Tests: Weight Variation: Ensures consistent weight across capsules. Conducted by weighing individual capsules and comparing with average weight. Moisture … Read more
Filling, Finishing, and Special Techniques of Formulation involve accurately transferring the formulated product into suitable containers, followed by sealing, labeling, and inspection to ensure quality. Specialized techniques enhance stability, efficacy, and product appeal. Filling, Finishing, and Special Techniques of Formulation also include advanced processes like lyophilization, aseptic processing, and microencapsulation to improve shelf-life, precision dosing, … Read more
Size of capsules refers to the standardized dimensions and volume of empty capsules used to encapsulate medicines or supplements. Capsule sizes range from 000 (largest) to 5 (smallest), based on fill volume. Choosing the right size of capsules ensures accurate dosing, ease of ingestion, and formulation efficiency. Hard gelatin capsules are available in various sizes, … Read more
Production of Hard gelatin capsules shells involves dipping stainless steel pins into a gelatin solution to form capsule halves. Production of Hard Gelatin Capsule Shells – Precise control in viscosity, temperature, and drying ensures consistent capsule quality for pharmaceutical use. The manufacturing of empty hard gelatin capsule shells is a specialized process often done on … Read more
