Medicinal Chemistry II

Triphelenamine Hydrochloride is a first-generation antihistamine known for its effectiveness in treating allergic conditions such as rhinitis, urticaria, and cold symptoms. Structure of Triphelenamine Hydrochloride Triphelenamine features a tricyclic structure with three benzene rings fused together, connected to an ethylamine side chain. The hydrochloride salt enhances solubility. Chemical Formula: C₁₄H₁₈N·HCl Mode of Action Blocks peripheral … Read more

Diphenylpyraline Hydrochloride is a first-generation antihistamine primarily used for the treatment of allergic conditions and cold-related symptoms. Structurally, it features two phenyl rings attached to a piperidine ring with a pyridine substitution, and its hydrochloride form enhances solubility. By acting as an H₁-receptor antagonist with anticholinergic properties, it effectively blocks the effects of histamine, providing … Read more

This article explains about Clemastine Fumarate, a first-generation antihistamine used for allergy relief, its actions, and therapeutic applications. Structure of Clemastine Fumarate Clemastine is a first-generation antihistamine featuring a piperidine ring substituted with a dibenzocycloheptene moiety. It forms a salt with fumaric acid to enhance stability. Chemical Formula: C₂₀H₂₇NO₂·C₄H₆O₄ Mode of Action Blocks peripheral H₁ … Read more

Below we have described about the uses of Doxylamine Succinate as a sedating antihistamine in allergy relief, cold symptoms, and sleep aid treatment. Structure of Doxylamine Succinate It is a first-generation antihistamine with a tricyclic structure. It is paired with succinic acid to form a salt, improving solubility. Chemical Formula: C₁₉H₂₉NO₃·C₄H₆O₄ Mode of Action Functions … Read more

Discover how Dimenhydrinate is used to prevent motion sickness and nausea, including its mechanism and therapeutic effects. Structure of Dimenhydrinate Dimenhydrinate is a combination of diphenhydramine and 8-chlorotheophylline. It forms a hydrate salt, enhancing its pharmacokinetic properties. Chemical Formula: C₁₉H₂₆ClN₃O·H₂O Mode of Action Acts primarily as an H₁-antagonist to reduce histamine-induced symptoms. The theophylline component … Read more

Learn about Diphenhydramine Hydrochloride, its uses as an antihistamine, mechanism of action, and role in allergy and cold treatment. Structure Diphenhydramine hydrochloride is a first-generation antihistamine characterized by two phenyl rings connected by an ethylamine chain. The chemical structure includes: Two benzene rings (diphenyl) An ether linkage (-O-) between them An ethyl chain ending with … Read more

This article explains about the Structure-Activity Relationship (SAR) of H1 receptor antagonist antihistamines and their role in allergy treatment. Structure-Activity Relationship (SAR) of H1 receptor antagonist antihistamines The SAR of H₁ receptor antagonists outlines how their chemical structures influence their ability to block H₁ histamine receptors. Key structural components include aromatic substitutions, the linker atom … Read more

This article explains about the histamine receptor their types functions and how they influence allergic reactions immune responses and other physiological effects. Histamine Receptor: Histamine exerts its effects by binding to four types of histamine receptors, all of which are G protein-coupled receptors (GPCRs): H₁ Receptor H₂ Receptor H₃ Receptor H₄ Receptor Each receptor subtype … Read more

Below we have described the classification of antihistamine based on receptor type and generation with their roles in allergy relief and related conditions. Classification of antihistamine: The medications listed can be classified into three main categories: H1-antagonists (antihistamines), H2-antagonists (histamine H2 receptor blockers), and gastric proton-pump inhibitors (PPIs). Below is a proper classification of each: … Read more

Discover how H-1 antagonists work to treat allergies by blocking histamine receptors and explore their types and common uses. H1 antagonists, also known as H1 blockers or antihistamines, are a class of drugs that inhibit the action of histamine at the H1 receptor sites. They are widely used to treat various allergic conditions and are … Read more