Formulation and Manufacture of Aerosols

Formulation and Manufacture of Aerosols

Formulation and Manufacture of Aerosols involve selecting suitable propellants, solvents, and active ingredients for stability and delivery. Formulation and Manufacture of Aerosols also include filling, sealing, and quality control for efficient drug release. The formulation of aerosols requires careful selection and combination of ingredients to achieve desired performance. Formulation Components: Active Pharmaceutical Ingredient (API): Must … Read more

Terbutaline

Terbutaline

Terbutaline is a medication that belongs to the class of drugs known as beta-2 adrenergic agonists. It is primarily used as a bronchodilator to treat or prevent bronchospasm in conditions such as asthma, chronic bronchitis, and chronic obstructive pulmonary disease (COPD). Chemical Structure & Formula Chemical Formula: C₁₂H₁₉NO₃ Structure: Mechanism of Action (Detailed) Terbutaline is … Read more

Isoproterenol (Isoprenaline)

Isoproterenol (Isoprenaline)

Isoproterenol (also known as Isoprenaline) is a synthetic non-selective beta-adrenergic agonist used primarily as a bronchodilator and cardiac stimulant. It mimics the effects of the sympathetic nervous system by stimulating β1 and β2 adrenergic receptors, leading to increased heart rate (positive chronotropic effect). Chemical Structure & Formula Chemical Formula: C₁₁H₁₇NO₃ Structure: Mechanism of Action (Detailed) … Read more

Evaluation of Aerosols

Evaluation of Aerosols

Evaluation of Aerosols involves assessing their physical stability, valve function, spray pattern, and particle size. Evaluation of Aerosols also ensures therapeutic efficacy, container integrity, and consistent dose delivery throughout use. Evaluating the performance and safety of aerosol products involves several important tests to make sure they work properly and are safe to use. Here’s a … Read more

Dobutamine

Dobutamine

Dobutamine is a synthetic catecholamine, and a beta-1 adrenergic receptor agonist used primarily as a cardiac stimulant. It increases heart rate and the force of heart contractions, thereby improving cardiac output. Clinically, dobutamine is commonly used in the treatment of acute heart failure, cardiogenic shock, and during cardiac stress testing when a patient cannot exercise. … Read more

Structure-Activity Relationship (SAR) of H1 Receptor Antagonist Antihistamines

Structure-Activity Relationship (SAR) of H₁ Receptor Antagonist Antihistamines

This article explains about the Structure-Activity Relationship (SAR) of H1 receptor antagonist antihistamines and their role in allergy treatment. Structure-Activity Relationship (SAR) of H1 receptor antagonist antihistamines The SAR of H₁ receptor antagonists outlines how their chemical structures influence their ability to block H₁ histamine receptors. Key structural components include aromatic substitutions, the linker atom … Read more

Types of Aerosol Systems

Types of Aerosol Systems

Types of Aerosol Systems vary by formulation, such as solution, suspension, or emulsion-based delivery mechanisms. Pharmaceutical aerosol systems vary based on formulation type, application route, and dose delivery mechanism. Types of Aerosol Systems: Liquefied Gas Systems Propellants: Hydrocarbons or nitrous oxide. Mechanism: Propellant evaporates to expel product. Uses: Hairsprays, deodorants. Compressed Gas Systems Propellants: Nitrogen, … Read more

Valves

Valves

The valves regulate the release of the formulation and ensures accurate dosing. Components of a Valve System: Valve Cup: Secures the valve to the container. Gasket: Prevents leakage and ensures a tight seal. Actuator: The part pressed by the user to release the product. Stem: Serves as the channel for the product to travel during … Read more

Clonidine

Clonidine

Clonidine is a medication primarily used to treat high blood pressure (hypertension). It belongs to a class of drugs known as centrally acting alpha-2 adrenergic agonists. Clonidine works by stimulating alpha-2 receptors in the brain, which reduces sympathetic outflow from the central nervous system. Chemical Structure & Formula Chemical Formula: C₉H₉Cl₂N₃ Structure: Mechanism of Action … Read more

Containers

Definition of Container: The containers play a crucial role in maintaining the integrity of the aerosol system. The container house both the formulation and the propellant under pressure. The choice of container material depends on the nature of the product, the propellant, and the intended use. Types of Containers Materials Metal Container: Examples: Aluminum, Tin-plated … Read more

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