Lisinopril

Lisinopril

Lisinopril is an ACE inhibitor used to treat hypertension and heart failure by relaxing blood vessels and lowering blood pressure. Structure of Lisinopril It is a long-acting, non-proteinogenic amino acid derivative ACE inhibitor with a lysine moiety. Chemical Formula: C₁₉H₃₂N₂O₅ Mode of Action ACE Inhibition: Similar to other ACE inhibitors, lisinopril blocks the conversion of … Read more

Amiloride

Amiloride

Amiloride is a potassium-sparing diuretic used in hypertension and edema by inhibiting sodium reabsorption and conserving potassium in the kidneys. Structure of Amiloride Amiloride is a non-steroidal potassium-sparing diuretic with a benzothiadiazine core fused to a pyridine ring, containing amine groups. Chemical Formula: C₄H₇N₄O₃S₂ Mode of Action ENaC Inhibition: Blocks epithelial sodium channels (ENaC) in … Read more

Captopril

Captopril

Captopril is an ACE inhibitor used to treat hypertension and heart failure by blocking angiotensin-converting enzyme and lowering blood pressure. Structure of Captopril Captopril is the first synthetic ACE inhibitor, featuring a sulfhydryl (-SH) group attached to a proline moiety. Chemical Formula: C₉H₁₇NO₃S Mode of Action ACE Inhibition: Blocks the angiotensin-converting enzyme (ACE), preventing the … Read more

Anti-Hypertensive Agents

Anti-Hypertensive Agents

Anti-Hypertensive Agents are drugs used to lower high blood pressure and reduce the risk of heart attack, stroke, and kidney disease. Anti-hypertensive agents are drugs used to manage high blood pressure (hypertension). They work through various mechanisms to lower blood pressure and reduce the risk of complications like heart attack, stroke, and kidney failure. Classification … Read more

Hypertension

Hypertension

Hypertension commonly known as high blood pressure, is a chronic medical condition where the blood pressure in the arteries is persistently elevated. It increases the risk of heart disease, stroke, and other serious health issues. Blood Pressure Classification Category Systolic (mmHg) Diastolic (mmHg) Normal < 120 < 80 Pre-Hypertension 120 – 139 80 – 89 … Read more

Mannitol

Mannitol

Mannitol is an osmotic diuretic used to reduce intracranial and intraocular pressure by drawing fluid out through the kidneys. Structure of Mannitol Mannitol is a sugar alcohol with six hydroxyl groups, making it highly hydrophilic and osmotic. Chemical Formula: C₆H₁₄O₆ Mode of Action Osmotic Gradient Creation: Mannitol remains in the extracellular space, creating an osmotic … Read more

Timolol

Timolol

Timolol is a non-selective beta-blocker used to treat hypertension, angina, and glaucoma by reducing heart rate and intraocular pressure. Structure of Timolol Timolol is a non-selective beta-adrenergic receptor blocker featuring a diphenylmethanol structure with a secondary amine. Chemical Formula: C₁₅H₂₂N₂O₃ Mode of Action Beta-Blockade: Inhibits both β₁ and β₂ adrenergic receptors. Cardiac Effects: Reduces heart … Read more

Classification of Histamine

Classification of Histamine

Classification of Histamine: Based on receptor types—H1, H2, H3, and H4 Classification of Histamine: Involved in allergy, gastric acid, CNS, and immunity. Histamine is a biogenic amine derived from the decarboxylation of the amino acid histidine. It plays pivotal roles in immune responses, gastric acid secretion, and as a neurotransmitter. Synthesis: From the amino acid … Read more

Introduction to Autacoids

Introduction to Autacoids

Introduction to Autacoids: Local hormones like histamine, serotonin, prostaglandins. Introduction to Autacoids: Used in allergy, inflammation, and cardiovascular disorders. What Are Autacoids? Autacoids are biologically active substances produced within the body that act locally to regulate various physiological functions. Unlike hormones, which are secreted into the bloodstream and act on distant targets, autacoids exert their … Read more

Triamterene

Triamterene

Triamterene is a potassium-sparing diuretic used to treat edema and hypertension by reducing sodium reabsorption without potassium loss. Structure of Triamterene Triamterene is a non-steroidal potassium-sparing diuretic with a triazine ring structure attached to an aromatic moiety and amine groups. Chemical Formula: C₁₆H₁₅N₃O₃ Mode of Action ENaC Inhibition: Blocks epithelial sodium channels (ENaC) in the … Read more