B Pharmacy is a 4-year undergraduate program in India that provides comprehensive knowledge of drugs, healthcare, and pharmaceutical sciences. It prepares students for careers in the pharmaceutical industry, clinical research, and healthcare services.
This course builds a strong foundation for B Pharmacy Students all over the world.
Antigout Drugs: Classified as uricosuric agents, xanthine oxidase inhibitors, and anti-inflammatory agents. Gout is a form of inflammatory arthritis characterized by hyperuricemia and deposition of monosodium urate crystals in joints. Antigout Drugs are aimed at reducing uric acid levels and managing acute attacks. Classes of Anti-Gout Drugs Drugs for acute gout: NSAIDs (e.g., Indomethacin, Naproxen) … Read more
Aspirin: A non-steroidal anti-inflammatory drug (NSAID) used for pain, fever, and inflammation. Aspirin: Also prevents blood clots by inhibiting platelet aggregation. MOA: Irreversibly inhibits COX-1 and COX-2, blocking prostaglandin and thromboxane A2 synthesis, reducing pain, inflammation, fever, and platelet aggregation. Pharmacological Actions: Anti-inflammatory Analgesic (pain relief) Antipyretic (fever reduction) Antiplatelet (prevents clotting) Pharmacokinetics: Absorption: Rapid … Read more
Non-Steroidal Anti-Inflammatory Agents (NSAIDs) are a class of medications widely used for their analgesic, antipyretic, and anti-inflammatory properties. Non-Steroidal Anti-Inflammatory Agents (NSAIDs) inhibit COX enzymes to block prostaglandin synthesis. They are termed “non-steroidal” to distinguish them from corticosteroids, which are another major class of anti-inflammatory drugs. Therapeutic Effects: Analgesic Antipyretic Anti-inflammatory Mechanism of Action NSAIDs … Read more
Substance P is an undecapeptide belonging to the tachykinin neuropeptide family. It functions as a neurotransmitter and neuromodulator. Substance P: Acts on NK1 receptors in CNS and peripheral tissues. Synthesis: Neurons: Primarily synthesized in the central and peripheral nervous systems. Release: Released from sensory nerve endings in response to pain and inflammation. Functions of Substance … Read more
Bradykinin is a nonapeptide that functions as a potent vasodilator and mediator of inflammation. It is part of the kallikrein-kinin system. Bradykinin Plays a key role in inflammation and blood pressure regulation. Synthesis: Prekallikrein Activation: Kallikrein converts high-molecular-weight kininogen to bradykinins. Regulation: Degraded by angiotensin-converting enzyme (ACE), which is why ACE inhibitors increase bradykinins levels. Functions … Read more
Angiotensin refers to a family of peptides that play a critical role in regulating blood pressure, fluid balance, and electrolyte homeostasis. The most important member is Angiotensin II (Ang II). Synthesis and Activation: Renin Release: Produced by the kidneys in response to low blood pressure or low sodium levels. Angiotensinogen Conversion: Renin converts angiotensinogen (produced … Read more
Leukotrienes are eicosanoids derived from arachidonic acid via the lipoxygenase (LOX) pathway. Leukotrienes are primarily involved in immune and inflammatory responses. These three groups are collectively called eicosanoids, derived from arachidonic acid via the cyclooxygenase (COX) or lipoxygenase pathways. Major Leukotrienes: LTB4 (Leukotriene B4): Functions: Acts as a potent chemotactic agent, attracting neutrophils to sites … Read more
Thromboxanes are eicosanoids derived from arachidonic acid via the COX pathway, specifically from PGH2. Thromboxanes play significant roles in hemostasis and vascular function. These three groups are collectively called eicosanoids, derived from arachidonic acid via the cyclooxygenase (COX) or lipoxygenase pathways. Major Thromboxanes: TXA2 (Thromboxane A2): Functions: Promotes platelet aggregation and vasoconstriction, essential for blood … Read more
Prostaglandins act as autacoids, having diverse roles in inflammation, vascular function, and other processes. These three groups are collectively called eicosanoids, derived from arachidonic acid via the cyclooxygenase (COX) or lipoxygenase pathways. Prostaglandins are a group of physiologically active lipid compounds derived from arachidonic acid via the cyclooxygenase (COX) pathway. Synthesis: Arachidonic Acid Release: Phospholipase … Read more
Serotonin (5-Hydroxytryptamine or 5-HT) is a monoamine neurotransmitter derived from the amino acid tryptophan. 5-HT (5-Hydroxytryptamine) (Serotonin) influences a wide range of physiological and behavioral processes. Synthesis: From the amino acid tryptophan by tryptophan hydroxylase and subsequent decarboxylation. Storage: High concentration in enterochromaffin cells in the gut, platelets, and in the CNS as a neurotransmitter. … Read more
