Introduction Monophasic liquids are liquid dosage forms that consist of a single, homogenous phase. They are typically comprised of a solvent, one or more dissolved active pharmaceutical ingredients (APIs), and various excipients. In monophasic liquid dosage forms, the API and excipients are uniformly distributed throughout the liquid, ensuring consistent dosing and rapid absorption. These formulations … Read more
Solubility enhancement techniques are crucial in pharmaceutical development, as they improve the dissolution and bioavailability of poorly soluble drugs. Various approaches can be employed to enhance solubility specifically in liquid dosage forms: Cosolvency Description: Involves using water-miscible solvents (cosolvents) to increase drug solubility by altering solvent polarity. Examples: Propylene glycol, ethanol, glycerin, polyethylene glycol. Micellar … Read more
Excipients are inactive substances used alongside the active pharmaceutical ingredients (APIs) in drug formulations. They play a vital role in the stability, efficacy, and safety of the final dosage form. In liquid dosage forms, excipients can serve various functions, including solubilizing agents, preservatives, suspending agents, viscosity modifiers, emulsifying agents, and flavouring agents, among others. Here’s … Read more
Liquid dosage forms include solutions, suspensions, emulsions, syrups, and elixirs, among others. They offer several advantages and disadvantages compared to other dosage forms like solids or semisolids. Advantages of liquid dosage forms: Ease of administration: Liquid dosage forms are generally easy to swallow, making them suitable for paediatric, geriatric, or dysphagic patients who may have … Read more
Geometric dilution is a compounding technique used in pharmacy to achieve a homogeneous mixture when combining ingredients with significantly different quantities. This method ensures even distribution of a potent active ingredient with a larger amount of diluent or excipient, which is crucial for maintaining accurate dosing and consistent therapeutic effects. Steps in Geometric Dilutions: Start … Read more
Eutectic Mixture can present challenges during the formulation, compounding, and storage of the final product. Eutectic Mixture may also impact the drug release profile, bioavailability, and overall therapeutic efficacy of the final product. When two or more components in a powder formulation form a eutectic mixture, they can create a mass that is sticky, pasty, … Read more
Hygroscopic powders are pharmaceutical powders that tend to absorb moisture from the environment. These powders can readily take up water vapor from the atmosphere and may even become wet or form a solution under highly humid conditions. Hygroscopic powders can be found in various pharmaceutical formulations, such as bulk powders, divided powders, or as components … Read more
Efflorescent powders refer to a class of pharmaceutical powders that contain hydrates, which are substances that have water molecules incorporated into their crystal structure. When these hydrates are exposed to a low-humidity environment or are subjected to heat, they can release water molecules, a process known as efflorescence. Although efflorescent powders aren’t a specific type … Read more
Effervescent powders are pharmaceutical dosage forms that, when dissolved in water or another liquid, produce a fizzy, carbonated solution. They typically contain an active pharmaceutical ingredient (API), along with a mixture of an acid and a base, which react to generate carbon dioxide gas when in contact with water. Effervescent powders are commonly used for … Read more
Dusting powders are topical pharmaceutical powders applied to the skin or mucous membranes for various therapeutic purposes. They are usually formulated with active ingredients and inert excipients to create a finely ground, free-flowing powder. Dusting powders can be used to treat various skin conditions, reduce friction, absorb moisture, or provide a cooling sensation. Types of … Read more
