Physical Pharmaceutics I

Mechanisms of Solute-Solvent Interactions

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Solute-Solvent Interactions & Solubility is largely determined by the interactions between solute and solvent molecules. Steps Involved in the Dissolution of a Solute Detachment of Solute Particles: Solute particles separate from the bulk solute. Requires energy to overcome intermolecular forces. Formation of Vacant Sites in Solvent: Solvent molecules rearrange to create vacant sites. These sites … Read more

Solubility Expressions

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Solubility Expressions

Solubility Expressions is a fundamental concept in physical pharmaceutics that influences the formulation, efficacy, and bioavailability of drugs. Understanding the solubility of drugs is crucial for developing effective pharmaceutical products. Solubility can be expressed in various ways, depending on the context and the required precision: Qualitative Solubility Expressions: Very Soluble: Less than 1 part solvent … Read more