Ideal solubility parameters provide a quantitative measure of the solubility of substances. They are based on the concept that similar intermolecular forces between solute and solvent lead to better solubility. The most common parameter is the Hildebrand solubility parameter (δ), which is defined as: $\delta = \sqrt{\frac{\Delta H_v – RT}{V_m}}$ Where: ΔHv = Enthalpy of … Read more
Solute-Solvent Interactions & Solubility is largely determined by the interactions between solute and solvent molecules. Steps Involved in the Dissolution of a Solute Detachment of Solute Particles: Solute particles separate from the bulk solute. Requires energy to overcome intermolecular forces. Formation of Vacant Sites in Solvent: Solvent molecules rearrange to create vacant sites. These sites … Read more
Solubility Expressions is a fundamental concept in physical pharmaceutics that influences the formulation, efficacy, and bioavailability of drugs. Understanding the solubility of drugs is crucial for developing effective pharmaceutical products. Solubility can be expressed in various ways, depending on the context and the required precision: Qualitative Solubility Expressions: Very Soluble: Less than 1 part solvent … Read more
