Chlorpheniramine Maleate is a widely used first-generation antihistamine effective in treating various allergic conditions, including rhinitis, urticaria, and cold-related symptoms. Structurally, it features a dibenzyl framework linked to an ethylamine chain and forms a salt with maleic acid to enhance solubility. It works by blocking both peripheral and central H₁ receptors, producing antihistaminic, anticholinergic, and mild sedative effects.
Structure of Chlorpheniramine Maleate
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- Chlorpheniramine is a first-generation antihistamine with a dibenzyl structure connected to an ethylamine chain.
- It forms a salt with maleic acid to enhance solubility.
- Chemical Formula: C₁₇H₂₈ClN₃·C₄H₄O₄
Mode of Action
- Blocks H₁-receptors both peripherally and centrally, reducing allergic symptoms.
- Exhibits anticholinergic and sedative effects.
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Uses
- Allergic Rhinitis: Relieves symptoms such as sneezing, itching, and runny nose.
- Urticaria: Alleviates hives and skin itching.
- Cold Symptoms: Helps reduce nasal congestion and other cold-related symptoms.
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