Introduction to Chlorpropamide:
Chlorpropamide is a first-generation sulfonylurea antidiabetic drug used in the treatment of type 2 diabetes mellitus. It helps lower blood sugar by stimulating pancreatic insulin secretion, thereby enhancing the body’s natural ability to regulate glucose levels. As one of the earliest oral hypoglycemic agents, it plays an important role in improving glycemic control and reducing diabetes-related complications.
Structure of Chlorpropamide
- It is a second-generation sulfonylurea with chlorinated aromatic rings, enhancing its potency compared to first-generation agents.
- Chemical Formula: C₁₇H₂₄ClN₃O₃S
Mode of Action
- Similar to Tolbutamide: Blocks K⁺ channels, promotes insulin secretion.
- Longer Duration: Provides extended insulinotropic effects.
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Uses
- Type 2 Diabetes Mellitus: Maintains blood glucose levels by increasing insulin secretion.
- Gestational Diabetes: Used under strict medical supervision.
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