Chlorprothixene

  • Chlorprothixene is a typical antipsychotic blocking dopamine receptor to reduce psychotic symptoms.
  • Its schizophrenia, anxiety, and agitation with calming effects.

Chemical Formula:

  • C₁₈H₁₈ClNS

 Chemical Structure of Chlorprothixene

Mechanism of Chlorprothixene:

  • D2 receptor antagonist (typical antipsychotic)
  • Also blocks H1, M1, α1 receptors
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Uses of Chlorprothixene:

  • Schizophrenia
  • Severe agitation
  • Mania (adjunct)

Side Effects:

  • Sedation
  • Anticholinergic effects
  • Moderate EPS

Notes:

  • Similar to chlorpromazine in potency
  • High sedative effect due to histaminergic blockade

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