This article explains about Clemastine Fumarate, a first-generation antihistamine used for allergy relief, its actions, and therapeutic applications.
Structure of Clemastine Fumarate
- Clemastine is a first-generation antihistamine featuring a piperidine ring substituted with a dibenzocycloheptene moiety.
- It forms a salt with fumaric acid to enhance stability.
- Chemical Formula: C₂₀H₂₇NO₂·C₄H₆O₄
Mode of Action
- Blocks peripheral H₁ receptors to reduce allergic responses.
- Exhibits minimal penetration of the blood-brain barrier compared to other first-generation antihistamines, resulting in less sedation.
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Uses
- Allergic Rhinitis: Treats symptoms like sneezing, itching, and runny nose.
- Urticaria: Relieves hives and skin itching.
- Cold Symptoms: Helps reduce nasal congestion and runny nose.
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