Clofibrate is a lipid-lowering drug used to reduce triglyceride levels and manage hyperlipidemia by activating lipid metabolism.
Structure of Clofibrate
- Clofibrate is a fibrate derivative with a benzofurazan core structure, characterized by two chlorine atoms and a carboxylic acid group.
- Chemical Formula: C₁₄H₁₉Cl₂N₃O₄S
Mode of Action
- PPAR-α Agonist: Activates peroxisome proliferator-activated receptor alpha (PPAR-α), regulating lipid metabolism.
- Triglyceride Reduction: Enhances the oxidation of fatty acids, leading to decreased triglyceride levels.
- HDL-C Increase: Increases high-density lipoprotein cholesterol (HDL-C) levels.
- VLDL-C Reduction: Lowers very-low-density lipoprotein cholesterol (VLDL-C) levels by reducing hepatic secretion.
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Uses
- Hypertriglyceridemia: Lowers elevated triglyceride levels in the blood.
- Dyslipidemia: Manages abnormal lipid profiles by reducing total cholesterol and LDL-C levels.
- Prevention of Atherosclerosis: Reduces the risk of atherosclerotic cardiovascular diseases by improving lipid profiles.
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