Clopidogrel is an antiplatelet drug that prevents strokes and heart attacks by inhibiting platelet aggregation.
Structure of Clopidogrel
- Clopidogrel is a thienopyridine class antiplatelet agent featuring a thiophene ring attached to a pyridine moiety with a chlorophenyl group.
- Chemical Formula: C₁₅H₁₂ClNO₂S
Mode of Action
- P2Y₁₂ Receptor Inhibition: Irreversibly blocks the P2Y₁₂ ADP receptor on platelet cell membranes.
- Platelet Aggregation Prevention: Inhibits ADP-mediated activation of glycoprotein GPIIb/IIIa, preventing fibrinogen binding and platelet aggregation.
- Thrombus Prevention: Reduces the formation of blood clots in arteries and veins.
Uses
- Acute Coronary Syndrome (ACS): Reduces the risk of heart attack and stroke in patients with ACS.
- Percutaneous Coronary Intervention (PCI): Prevents stent thrombosis in patients undergoing PCI.
- Secondary Prevention of Myocardial Infarction and Ischemic Stroke: Lowers the risk of recurrent cardiovascular events.
- Peripheral Artery Disease (PAD): Manages and prevents thrombotic complications in PAD patients.
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