- Clozapine treats resistant schizophrenia, reducing hallucinations, delusions, and suicidal risk.
- It treats resistant schizophrenia, reducing hallucinations, delusions, and suicidal risk.
Chemical Formula:
- C₁₈H₁₉ClN₄
Mechanism of Clozapine:
- Weak D2 antagonist, strong 5-HT2A, D4 antagonist
- Also affects M1, H1, α1 receptors
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Uses of Clozapine:
- Treatment-resistant schizophrenia
- Reduction of suicide risk in schizophrenia
Side Effects:
- Agranulocytosis (requires WBC monitoring)
- Seizures (dose-related)
- Weight gain
- Sedation
- Hypersalivation
- Low EPS risk
Notes:
- First true atypical antipsychotic
- Limited by serious side effects but highly effective
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