Colestipol

Colestipol is a bile acid sequestrant used in hyperlipidemia to lower LDL cholesterol by preventing bile acid reabsorption.

Structure of Colestipol

• Colestipol is a non-absorbed, cross-linked polyallylamine derivative with quaternary ammonium groups, functioning as a bile acid sequestrant.
• Chemical Formula: (C₃H₇NCl)ₙ(C₇H₁₅O₄S)ₙ

Mode of Action

• Bile Acid Sequestration: Binds bile acids in the gastrointestinal tract, preventing their reabsorption.
• Cholesterol Synthesis Reduction: Increases the conversion of cholesterol to bile acids in the liver.
• LDL-C Lowering: Enhances clearance of LDL-C from the bloodstream by upregulating hepatic LDL receptors.

Uses

• Hypercholesterolemia: Reduces LDL-C and total cholesterol levels.
• Type 2 Diabetes Mellitus: Used in combination with insulin or other hypoglycemic agents to manage hyperlipidemia.
• Diarrhea Management: Treats bile acid-induced diarrhea by sequestering excess bile acids.

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