Complexation and Drug Action - Free Topic Wise Notes

Complexation and Drug Action is the process where a central atom or ion forms a complex with one or more ligands.
In the context of drug action, complexation can influence various aspects of a drug’s pharmacokinetic and pharmacodynamic properties, ultimately affecting its therapeutic efficacy.
1. Solubility Enhancement: Complexation can improve the solubility of poorly soluble drugs, leading to better absorption and bioavailability.
2. Stability Improvement: Complexation can protect drugs from degradation (e.g., oxidation, hydrolysis), prolonging their shelf life and effectiveness.
3. Controlled Release: Complexation with responsive ligands can modulate drug release from various drug delivery systems, allowing for controlled release and improved therapeutic outcomes.
4. Targeted Drug Delivery: Complexation with specific ligands can facilitate targeted drug delivery to specific tissues, cells, or receptors, improving drug efficacy and reducing side effects.