- Compression and processing problems is the final step in tablet manufacturing, where granules are pressed into solid tablets using a tablet press.
- Compression and Processing Problems
• Definition: Issues encountered during tablet manufacturing affecting quality, uniformity, or efficiency.
• Causes: Poor formulation, improper equipment settings, or environmental conditions.
• Impact: Defects like capping, lamination, or sticking - Several challenges can arise during compression:
Compression Problem:
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- Capping: Tablet top or bottom separates due to low tensile strength or high compression force.
- Lamination: Splitting into layers caused by uneven stress distribution.
- Picking/Sticking: Material adheres to punches, causing incomplete tablets and contamination.
- Mottling: Uneven color distribution due to inconsistent mixing.
- Elastic Rebound: Tablets expand after compression, reducing hardness.
- Erosion: Surface material loss leads to weight variation.
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Processing Problems:
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- Poor Flowability: Uneven feeding causes weight variation.
- Dust Formation: Material loss and inhalation hazards.
- Moisture Issues: Stickiness affects hardness and disintegration.
- Temperature Control: Heat-sensitive drugs may degrade.
- Equipment Wear: Punches and dies wear out, reducing tablet quality
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