Cortisone is a corticosteroid used to relieve inflammation and treat conditions like arthritis, allergies, and adrenal insufficiency.
Structure of Cortisone
- Cortisone is a synthetic corticosteroid with a cyclopentanoperhydrophenanthrene structure, featuring hydroxyl and keto functional groups.
- Chemical Formula: C₂₂H₂₈O₅
Mode of Action
- Glucocorticoid Activity: Binds to glucocorticoid receptors, regulating gene expression involved in inflammatory and immune responses.
- Anti-Inflammatory Effects: Reduces inflammation by inhibiting pro-inflammatory cytokines and mediators.
- Immunosuppression: Suppresses the immune system, reducing hypersensitivity and autoimmune responses.
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Uses
- Inflammatory Conditions: Treats arthritis, asthma, and allergic reactions by reducing inflammation.
- Autoimmune Diseases: Manages conditions like lupus and multiple sclerosis through immunosuppression.
- Endocrine Disorders: Used in adrenal insufficiency to replace deficient cortisol.
- Skin Conditions: Applied topically to treat dermatitis, eczema, and psoriasis.
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