Cromolyn Sodium is a mast cell stabilizer widely used in the treatment of allergic conditions such as asthma, allergic rhinitis, and conjunctivitis. Unlike typical antihistamines, it does not block H₁ receptors directly but works by preventing the release of histamine and other inflammatory mediators from sensitized mast cells. Its unique chemical structure, a polysulfated derivative of benzilic acid, plays a vital role in its mechanism of action and therapeutic benefits.
Structure of Cromolyn Sodium
- It is a polysulfated derivative of benzilic acid, featuring multiple sulfonate groups attached to a benzene ring.
- Chemical Formula: C₂₀H₁₈Na₂O₁₀S₂
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Mode of Action
- Stabilizes mast cells, preventing the release of histamine and other inflammatory mediators.
- It does not directly block H₁ receptors but inhibits the cellular response to histamine.
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Uses
- Asthma: Prevents and controls asthma symptoms by inhibiting mast cell degranulation.
- Allergic Rhinitis: Reduces nasal congestion and other allergic symptoms.
- Conjunctivitis: Alleviates eye irritation and redness caused by allergies.
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