Cyclophosphamide is a widely used alkylating anti-cancer drug that targets DNA to treat lymphomas, leukemias, and solid tumors.
Structure of Cyclophosphamide
- Cyclophosphamide is a prodrug alkylating agent with a nitrogen mustard structure attached to a phosphoramide moiety.
- Chemical Formula: C₈H₁₅Cl₂N₂O₂P
Mode of Action
- Prodrug Activation: Metabolized in the liver to form active metabolites (phosphoramide mustard and acrolein).
- DNA Alkylation: Phosphoramide mustard forms crosslinks with DNA, inhibiting replication and transcription.
- Cell Death: Induces apoptosis in rapidly dividing cancer cells.
Advertisements
Uses
- Lymphomas: Hodgkin’s and non-Hodgkin’s lymphoma.
- Leukemias: Various forms.
- Breast Cancer: As part of combination chemotherapy.
- Ovarian Cancer: Treatment and prevention of recurrence.
- Autoimmune Diseases: Such as rheumatoid arthritis and lupus (off-label uses).
Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!
