Desflurane

• Desflurane enhances GABA effects in the CNS, offering fast onset, easy control, and quick recovery.
• It is an inhalation anesthetic used for rapid induction and maintenance of general anesthesia.

Chemical Formula:

• C₃H₂F₆O

Mechanism of Desflurane:

• Similar to isoflurane
• Rapid onset/recovery due to low blood solubility

Uses of Desflurane:

• Outpatient surgery (day-case anesthesia)
• Maintenance (not ideal for induction)

Side Effects:

• Airway irritation, coughing, laryngospasm
• Tachycardia, hypertension (initial)
• Least metabolized = minimal organ toxicity

Notes:

• Requires special heated vaporizer
• Rapid changes in depth of anesthesia possible

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