Diazoxide is a vasodilator used in hypertensive emergencies by relaxing arterioles and rapidly reducing blood pressure.
Structure of Diazoxide
- Diazoxide is a benzothiadiazine derivative with an open ring structure, containing a sulfonamide group and a hydroxyl substituent.
- Chemical Formula: C₈H₇N₃O₃S
Mode of Action
- Potassium Channel Opener: Activates ATP-sensitive potassium channels in vascular smooth muscle.
- Hyperpolarization: Causes hyperpolarization of smooth muscle cells, leading to vasodilation.
- Insulin Release Inhibition: Suppresses insulin secretion from pancreatic beta cells.
Advertisements
Uses
- Hypertension: Induces vasodilation in hypertensive patients.
- Hypoglycemia: Prevents insulin-induced hypoglycemia by inhibiting insulin release.
- Hyperinsulinism: Manages conditions with excessive insulin secretion.
- Hypertensive Crises: Provides rapid blood pressure reduction in acute settings.
Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!
