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Fick’s Laws of Diffusion Principles in Biological Systems :
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First Law:
- States that the rate of diffusion is proportional to the concentration gradient.
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Describes the flux of molecules $J = -D \frac{dC}{dx}$
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J is the flux; D is the diffusion coefficient $\frac{dC}{dx}$
, is the concentration gradient
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Second Law:
- Explains that diffusion causes changes in concentration over time.
Permeability Coefficient (P):
Determines the rate at which a drug diffuses across a membrane.
Partition Coefficient (K):
Ratio of concentrations of a compound in a mixture of two immiscible phases at equilibrium.
Factors Affecting Diffusion Principles in Biological Systems:
Molecular size, lipophilicity, ionization state, and membrane properties.
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