Digitoxin is a cardiac glycoside that treats CHF by improving heart pumping efficiency and controlling heartbeat.
Structure of Digitoxin
- Digitoxin is a cardiac glycoside similar to digoxin but with a longer half-life due to fewer hydroxyl groups on the steroid nucleus.
- Chemical Formula: C₄₉H₇₄O₁₉
Mode of Action
- Na⁺/K⁺-ATPase Inhibition: Similar to digoxin, inhibits the sodium-potassium pump, increasing intracellular calcium.
- Positive Inotropic Effect: Enhances myocardial contractility.
- Vagal Stimulation: Increases parasympathetic tone, reducing heart rate.
Advertisements
Uses
- Heart Failure: Improves cardiac output and symptoms in chronic heart failure.
- Atrial Fibrillation and Flutter: Controls ventricular rate by reducing AV node conduction.
- Supraventricular Tachycardias: Manages rapid heart rhythms effectively.
Thank you for reading from Firsthope's notes, don't forget to check YouTube videos!
