- Diphenoxylate Hydrochloride is an opioid derivative acting on gut receptors with minimal CNS effect.
- It is used to treat diarrhea by slowing intestinal motility.
Chemical Formula:
- C₃₀H₃₂ClNO₂
Mechanism of Action:
- μ-opioid agonist → inhibits GI motility
- Has no significant analgesic effect at therapeutic doses
Therapeutic Uses of Diphenoxylate Hydrochloride:
- Antidiarrheal (combined with atropine in Lomotil)
- Atropine discourages abuse
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Side Effects of Diphenoxylate Hydrochloride:
- Dry mouth
- Drowsiness
- Abdominal discomfort
- High doses → euphoria, respiratory depression
Notes:
- Structurally related to meperidine
- At high doses has CNS opioid activity
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