Diphenylpyraline Hydrochloride is a first-generation antihistamine primarily used for the treatment of allergic conditions and cold-related symptoms. Structurally, it features two phenyl rings attached to a piperidine ring with a pyridine substitution, and its hydrochloride form enhances solubility. By acting as an H₁-receptor antagonist with anticholinergic properties, it effectively blocks the effects of histamine, providing relief from symptoms such as sneezing, itching, and nasal congestion.
Structure of Diphenylpyraline Hydrochloride
- Diphenylpyraline consists of two phenyl rings linked to a piperidine ring with a pyridine substitution.
- The hydrochloride salt increases its solubility.
- Chemical Formula: C₁₉H₂₇ClN₂O·HCl
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Mode of Action
- Acts as an H₁-receptor antagonist with additional anticholinergic effects.
- It blocks the action of histamine, reducing allergic symptoms.
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Uses
- Allergic Reactions: Effective in treating symptoms of allergies such as itching, sneezing, and runny nose.
- Cold Symptoms: Alleviates nasal congestion and other cold-related discomforts.
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