Droperidol

• Droperidol is a dopamine antagonist with sedative, antiemetic, and antipsychotic effects.
• It controls nausea, vomiting, and agitation in surgical and psychiatric settings.

Chemical Formula:

• C₂₂H₂₂FN₃O₂

Mechanism of Droperidol:

• Potent D2 blocker
• Also blocks alpha-adrenergic and 5-HT3 receptors

Uses of Droperidol:

• Nausea/vomiting (post-op)
• Sedation in ICU
• Agitation (adjunct)

Side Effects:

• QT prolongation (boxed warning)
• EPS
• Sedation

Notes:

• Often used with fentanyl in neurolept anesthesia

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