Edrophonium Chloride

• Edrophonium Chloride is a short-acting, quaternary ammonium compound classified as a reversible acetylcholinesterase inhibitor.
• It temporarily increases acetylcholine levels at neuromuscular junctions by inhibiting the enzyme acetylcholinesterase.

Chemical Formula:

• C₁₀H₁₆ClNO
• 

Mechanism of Action:

• Short-acting reversible AChE inhibitor.
• Binds via electrostatic + hydrogen bonding, not covalent.

Uses of Edrophonium Chloride:

• Diagnosis of myasthenia gravis (Tensilon test)
• Reversal of neuromuscular blockade (short-term)

Side Effects of Edrophonium Chloride:

• Bradycardia
• Hypotension
• GI upset
• Lacrimation

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