- Enflurane enhances GABA activity, producing CNS depression with muscle relaxation and analgesia.
- It is an inhalation anesthetic used for induction and maintenance of general anesthesia.
Chemical Formula:
- C₃H₂ClF₅O
Mechanism of Enflurane :
- Enhances GABA-A activity
- Inhibits excitatory neurotransmission
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Uses of Enflurane:
- Maintenance of anesthesia (replaced by safer agents)
Side Effects:
- CNS excitation → seizure-like EEG activity
- Nephrotoxicity (fluoride release)
- Hypotension
- Respiratory depression
Notes:
- Moderate potency, pungent odor
- Use avoided in epileptic patients
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