Equipment for the Manufacture of Pellets

• Equipment for the Manufacture of Pellets involves specialized machinery for producing uniform drug-loaded spheres. It includes mixers, extruders, and spheronizers essential for granulation, shaping, and rounding processes.
• Equipment for the Manufacture of Pellets ensures efficiency, quality, and scalability in pharmaceutical pellet production, meeting dosage uniformity and controlled-release requirements.
• The choice of equipment depends on the pelletization method used. Key machines include:

1. Mixer/Granulator:

   • Prepares the wet mass or powder mixture.
   • Examples: High-shear mixers, planetary mixers.

2. Extruder:

   • Converts the wet mass into cylindrical extrudates.

   • Types:

     • Axial Extruder: Extrudate is forced through a die using a screw mechanism.
     • Radial Extruder: Extrudate exits radially from a rotating die.
     • Basket Extruder: Produces highly uniform extrudates.

3. Spheronizer:

   • Rounds the extrudates into spherical pellets.
   • Consists of a rotating friction plate and walls to promote rounding through centrifugal and frictional forces.

4. Fluidized Bed Processor:

   • Used for layering, drying, or coating pellets.
   • Works by suspending pellets in a stream of air and applying coating materials.

5. Coating Pan:

   1. Used for applying drug or polymer coatings onto pellets.
   2. Features spray guns and a rotating pan.

6. Cryopelletizer:

   • For cryopelletization, where liquid formulations are dropped into a freezing medium like liquid nitrogen.

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